Designing materials to direct stem-cell fate
WebFeb 2, 2024 · Most design strategies for fabricating stem cell-laden tissue engineered scaffolds can be classified into one of the two categories. The first approach, top-down, focuses on designing the extracellular environment to contain the appropriate signals for guiding the differentiation of stem cells towards the lineage of choice. WebNov 1, 2013 · However, in vivo cell fate is likely influenced by a combination of geometry, mechanics and ECM composition [21], [22]. Thus we reasoned that combining these cues would prove useful in designing materials that more closely emulate the in vivo microenvironment and “fine-tune” a desired differentiation outcome.
Designing materials to direct stem-cell fate
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WebNov 27, 2012 · As stem cells are a cornerstone of regenerative medicine, research efforts have been extensively focused on controlling their self-renewal and differentiation. It is … WebNov 25, 2009 · Designing 3D materials to control stem-cell fate in vitro Whereas 2D approaches allow well-controlled analysis of the impact on …
WebApr 9, 2024 · Stem cell therapy has broad application prospects in the repair of brain injury. One of the major challenges is exogenous NSCs differentiating into neurons. More recently, a variety of engineered fibrous scaffolds have been beneficial to the fate regulation of stem cells, thus promoting neural repair. WebApr 16, 2024 · Studies of stem cell behavior on soft biomaterials have typically employed 2D platforms of synthetic polymers coated with monomeric protein ligands ().Such studies (2–4) have demonstrated that modulating the stiffness of porous gels can direct stem cell fate.However, experimental outcomes on amorphous biomaterial substrates vary widely.
WebAug 10, 2014 · Stem cells regulate their fate by binding to, and contracting against, the extracellular matrix. ... H. M. Designing materials to direct stem-cell fate. Nature 462, 433–441 (2009). Article CAS ... WebSep 26, 2011 · MP Lutolf, PM Gilbert, HM Blau, Designing materials to direct stem-cell fate. Nature 462, 433–441 (2009). Crossref. PubMed. Google Scholar. 14. T Lecuit, PF Lenne, Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis. Nat Rev Mol Cell Biol 8, 633–644 (2007).
WebMar 1, 2015 · The primary research interest of his group is to develop and integrate nanotechnologies and chemical biology to modulate signaling pathways in stem cells and cancer cells towards specific cell ...
WebAs stem cells are a cornerstone of regenerative medicine, research efforts have been extensively focused on controlling their self-renewal and differentiation. It is well-known that stem cells are tightly regulated by a combination of physical and chemical factors from their complex extracellular surroundings; thus, conventional cell culture approaches based … billy no mates expressionWebBiomaterials are rapidly being developed to display and deliver stem-cell-regulatory signals in a precise and near-physiological fashion, and serve as powerful artificial … cynsew gmail.comWebNov 8, 2012 · It is well-known that stem cells are tightly regulated by a combination of physical and chemical factors from their complex extracellular surroundings; thus, … cyn santana ethnic backgroundWebThe materials pipeline for biomaterials and tissue engineering applications is under continuous development. Specifically, there is great interest in the use of designed materials in the stem cell arena as materials can be … cynsational photographyWebCell therapies hold great clinical promise, but control of transplanted cell fate remains a significant challenge 1.Material-based transplantation systems offer a promising means to control cell fate for regeneration of functional tissue or controlled disease ablation 2, 3.As cell-matrix interactions are central to eukaryote biology 4, 5, these materials systems … cyn santana boyfriend 2022WebNov 8, 2012 · A new paradigm in biomaterial design—targeting glycosaminoglycans (GAGs) to regulate stem cell fate. In line with previously stated methods of using … cy-nsgycl win11cynsd insurance